Health Technologies

Is digital twin technology a viable route to treating pain?

By Prof Mick Thacker, Dr Kate Ryan and Leslie Pan

Pain, particularly musculoskeletal (MSK) pain, is both pervasive and complex.

Globally, approximately 1.71 billion people suffer from MSK conditions, which account for the leading cause of disability worldwide, with lower back pain being the single biggest contributor across 160 countries [1].

In the UK alone, between one-third and one-half of adults – just under 28 million people – live with chronic pain, with prevalence rising to 62 per cent among those over 75 [2].

This burden is both physical and economic. MSK pain reduces mobility, impairs productivity, and often intersects with

  • Fayaz A, Croft P, Langford RM, Donaldson LJ, Jones GT. Prevalence of chronic pain in the UK: a systematic review and meta-analysis. BMJ Open. 2016;6(6):e010364. doi:10.1136/bmjopen-2015-010364
  • Stanford Medicine. Medical digital twins: shaping the future of personalised healthcare. 2023. Available at: https://med.stanford.edu/medicine/news/current-news/standard-news/medical-digital-twins.html
  • The Wall Street Journal. A digital twin of your heart could help doctors treat you. 2024. Available at: https://www.wsj.com/health/healthcare/digital-heart-surgery-patient-treatment-c35ec4be
  • Liu W, Zhang Y, et al. Digital Twins in Healthcare: Current Applications and Future Opportunities. Frontiers in Digital Health. 2025. PMID: 12294331
  • Ojo A, et al. Digital twins for healthcare: barriers and enablers. npj Digital Medicine. 2023. PMID: 10686591
  • Avoiding growing pains in the development and use of digital twins. 20 Aug 2024. Available at: https://www.reuters.com/legal/legalindustry/avoiding-growing-pains-development-use-digital-twins-2024-08-20
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